Journal of Rare Cardiovascular Diseases
ISSN: 2299-3711 (Print)
e-ISSN: 2300-5505 (Online)
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Relationship of Glycemic Control with Kidney Function Tests and Lipid Profile in Type 2 Diabetes Mellitus Patients in a Tertiary Care Hospital
Uma Kant Chaudhari
Juhi Aggarwal
Jyoti Batra
Ashok Kumar
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1
PhD Scholar, Department of Biochemistry, Santosh Medical College & Hospital, Santosh Deemed to be University, Ghaziabad, NCR Delhi.
2
Professor & HOD, Department of Biochemistry, Santosh Medical College & Hospital, Santosh Deemed to be University, Ghaziabad, NCR Delhi.
3
Research Dean & Professor, Department of Biochemistry, Santosh Medical College & Hospital, Santosh Deemed to be University, Ghaziabad, NCR Delhi.
4
Professor and Head, Department of General Medicine, Santosh Medical College & Hospital, Santosh Deemed to be University, Ghaziabad, NCR Delhi.
Received: 2025-08-07
Revised: 2025-09-12
Accepted: 2025-10-14
Published: 2025-11-10
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Abstract
Background: Diabetes causes both microvascular complications, which comprise neuropathy, nephropathy and retinopathy and macrovascular complications, which comprise cardiovascular disease, stroke, and peripheral vascular disease. The aim of this prospective research study is to investigate the relationship between blood glucose levels, kidney function, and lipid profile in patients diagnosed with type 2 diabetes mellitus (T2DM). The variations in blood glucose levels significantly influence renal function and lipid metabolism in individuals with T2DM. Material and Methods: This study was conducted at Santosh Medical College and Hospital, Ghaziabad, Uttar Pradesh. 125 pre-diagnosed type 2 diabetic patients were taken as the study group and the same number of healthy individuals were taken as the control group. Inclusion criteria will include a confirmed diagnosis of Type 2 diabetes mellitus, 18 to 70 years of age, and willingness to participate in the study. Fasting and postprandial blood sugar, glycated haemoglobin (HbA1c), serum creatinine, urine microalbumin, T.Chol., TG, HDL, LDL and VLDL were estimated in both groups. Result: In our study, we found that there is a significant (p-value = 0.0001) rise in FBS, PPBS and HbA1c in the study group as compared to the control group. Serum creatinine and urine microalbumin in the study group were found to be significantly (p-value = 0.0001) elevated in the study group as compared to the control group. In Lipid Profile parameters, Total cholesterol, triglycerides, LDL and VLDL were significantly (p-value = 0.0001) higher in the study group as compared to the control group but there was no significant (p-value = 0.0361) difference in HDL cholesterol level between these two groups.
Conclusion: A significant association of HbA1c with urine microalbumin and serum creatinine indicates that impaired blood glucose level causes nephropathy. This emphasizes the need for early detection of urine microalbuminuria in type 2 diabetic patients. Also, elevated blood glucose causes dyslipidemia which may cause cardiovascular disorders. The study suggests the need for effective diabetes control and the prevention of associated renal damage and cardiovascular risk factors. These findings may have implications for optimizing diabetes management strategies, including the importance of glycemic control in preserving kidney health and managing cardiovascular risk factors in this population.
Keywords
Type 2 diabetes; Glycemic control; Renal profile; Lipid parameters.
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Classification of Rare Cardiovascular Diseases
anticoagulation
atrial fibrillation
atrial septal defect
cardiomyopathy
computed tomography
congenital heart disease
echocardiography
electrocardiogram
electrocardiography
heart failure
implantable cardioverter‑defibrillator
magnetic resonance imaging
pregnancy
pulmonary arterial hypertension
pulmonary hypertension
rare cardiovascular disease
rare disease
right heart catheterization
right ventricular failure
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