Journal of Rare Cardiovascular Diseases
ISSN: 2299-3711 (Print)
e-ISSN: 2300-5505 (Online)
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Development of conditions for extraction of clozapine and olanzapine drugs from aqueous media using organic solvents and study of factors affecting them
Zokirova Gulruh Raxmatillayevna1
Jalilov Fazliddin Sodiqovich
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1
ALFRAGANUS University senior lecturer , Tashkent Pharmaceutical Institute, ALFRAGANUS University professor
Received: 2025-08-12
Revised: 2025-09-24
Accepted: 2025-10-14
Published: 2025-11-13
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Abstract
The article presents information on the therapeutic and toxic properties of the drugs clozapine and olanzapine and their analogues registered in the Republic of Uzbekistan. Factors influencing the extraction of clozapine and olanzapine from aqueous media, including the effect of organic solvents and pH of the medium, were also studied. Qualitative and quantitative analysis was carried out using a previously developed UV spectrophotometric method.
Keywords
Clozapine, UV spectrophotometry, absorption spectrum, specific absorption index, molar absorption index, validation parameters, calibration graph.
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Keywords
Classification of Rare Cardiovascular Diseases
anticoagulation
atrial fibrillation
atrial septal defect
cardiomyopathy
computed tomography
congenital heart disease
echocardiography
electrocardiogram
electrocardiography
heart failure
implantable cardioverter‑defibrillator
magnetic resonance imaging
pregnancy
pulmonary arterial hypertension
pulmonary hypertension
rare cardiovascular disease
rare disease
right heart catheterization
right ventricular failure
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