Aim: To perform a prospective study on risk of AKI in patients with DM and HTN. Objectives: To study the risk of patients with AKI in patients with DM and HTN. And To know the prevalence of the diseases in patients. Methodology: The study was conducted at aware Gleneagles global hospitals in L.B. Nagar, Hyderabad, over a 6 month’s period among 70 patients in the study. Patients of both genders, IP Patients, Age group: 18-90 years, Patients with comorbidities were included in the study. OP Patients, Pregnant patients, patients with CKD, patients with kidney transplantation, patients with surgical history, Neonates and pediatrics were excluded from the study. Any patient with comorbidities who are at risk of developing AKI had their information collected using a well-designed data collection form that included patient’s demographics, prescription charts, laboratory investigations, medical history and other required information. Result: A study of 70 patient records revealed a demographic split of 50 males (71.4%) and 20 females (28.6%). The data shows 67 patients had comorbid conditions, primarily DM and HTN. The 71-80 age group was disproportionately affected by AKI. (64.2%) Patients with both comorbid conditions, DM and HTN identified as most common cause for developing AKI, notably (27.1%) patients with only HTN and (8.5%) patients with only DM effected with AKI.Conclusion: This study examined 70 subjects affected by AKI, revealing varying prevalence rates among the participants over the study period.