Background: Transient tachypnea in newborns is a benign, self-limiting Cause of respiratory distress that leads to the admission of newborns to the NICU and requires prompt diagnosis and treatment. Therefore, this study aims to find the incidence, risk factors, and outcome of newborns with transient tachypnea based on clinical features. The secondary objective is to find the relation between Transient tachypnea and sepsis. Methods: This prospective observational study was conducted among newborns with Transient tachypnea admitted to the NICU (Neonatal Intensive Care Unit) of the Government General Hospital, Chittoor, from August 2022 to December 2022 after obtaining approval from the institutional ethics committee of Apollo Institute of Medical Science and Research, Chittoor. Results: The newborns included in our study were 61. The incidence was 21 cases per 1000 live births. The average gestational age of newborns was 38.1+1.75, and birth weight was determined to be 2.83+0.42. Neonates were part of the study following the inclusion criteria. Risk factors identified with TTNB are male sex, infants of mothers with pre-eclampsia, gestational diabetes mellitus, and severe anaemia. Outcome is predicted based on the Downs score at presentation and the length of respiratory distress following birth. Conclusion: According to this study, we concluded that the type of delivery is not a risk factor for the development of TTNB. Newborns with greater than 34 weeks of gestational age born to mothers with pre-eclampsia, diabetes mellitus, and severe anaemia have an increased risk of development of TTNB, higher downs score at presentation, and early respiratory distress and duration of distress greater than 24 hrs After admission, are linked to longer duration of hospital stay. Blood culture results obtained are inconclusive for the majority of cases, indicating the unnecessary usage of prophylactic antibiotics for TTNB.