Heyde’s syndrome is defined as a combination of gastrointestinal bleeding from a gastrointestinal angiodysplasia in patients with aortic stenosis. An acquired von Willebrand factor deficiency secondary to aortic stenosis is considered to be the major abnormality in Heyde’s syndrome. Management of Heyde’s syndrome requires cooperation of many different kinds of specialists: cardiologists, gastroenterologists, hematologists, general surgeons and cardiosurgeon. We present a care report of 62 years old female with no history of cardiovascular disorders referred to the Centre of Rare Cardiovascular Diseases in Kraków for cardiological evaluation of a heart murmur prior to a surgical procedure of a vascular malformation in colon. JRCD 2014; 1 (7): 17–20