Myxomas are the most common primary benign intracardiac tumors. Typically they locate in the left atrium (LA) or right atrium (RA) and are composed of cells, that originate from multipotent mesenchyme. The clinical manifestations of myxomas depend on the anatomic location of the tumor, its size, as well as its mobility. We present two case reports that concern the management of myxoma. The first diagnostic approach for assessment of the myxomas is two dimensional echocardiography. Computed tomography (CT) and Magnetic Resonance (MR) play especially role in providing diagnostic information useful toward surgical planning. Surgical operation and resection of the myxoma is a definite and curative therapy The risk for recurrence of the myxoma is about 2–5 %. The annual clinical surveillance and echocardiographic assesment is reccomended to all patients who undergo a myxoma operation.. JRCD 2013; 1 (4): 29–32