Background: Herpes Zoster (HZ) is a common viral infection, affecting the elderly and immunocompromised individuals. Despite the availability of preventive measures like the HZ vaccine, awareness of the disease and its complications remains limited in various populations. This study aims to assess the awareness and perceptions of Herpes Zoster among patients attending the outpatient department (OPD) at tertiary care centreMethods: A cross-sectional study was conducted from January 2024 to December 2024 in the Department of Dermatology, Venereology, and Leprosy at SRM Medical College Hospital and Research Centre. The study included 128 patients with a clinical diagnosis of Herpes Zoster attending the OPD. Data was collected using a structured questionnaire that covered sociodemographic details, clinical history, and awareness of HZ, its complications, recurrence, and vaccination. Descriptive statistics and Chi-square tests were used for data analysis.Results: Of the 128 participants, 50.8% had heard of Herpes Zoster, but only 25% could correctly recognize it as an viral infection. Knowledge about HZ complications and recurrence was limited, with 31.3% aware of post-herpetic neuralgia. Awareness of the HZ vaccine was low (29.7%), with concerns about side effects and cost being significant barriers. While 66.4% of participants sought medical treatment for HZ, some relied on pharmacists (18%) or traditional healers (7.8%), and 7.8% did not seek treatment.Conclusion: A significant knowledge gap regarding Herpes Zoster among the participants, was noted particularly concerning its complications, recurrence, and preventive measures like vaccination.