Thisstudyinvestigated the hematological, inflammatory, and genetic responses in oil sector workers exposed to long-term and short-term environmental toxins. A total of 300 participants were included: 100 with long-term exposure, 100 with short-term exposure, and 100 controls. Blood samples were collected after overnight fasting for hematological assays, DNA extraction, malondialdehyde (MDA) assays, glycemic determination, and interleukin-6 (IL-6) analysis. The TP53 codon72(rs1042522)polymorphismwasgenotypedusingRFLP-PCR.Resultsrevealedasignificantdecreaseinhemoglobin concentration and asignificantincrease inerythrocyte sedimentation rate (ESR)inbothexposedgroupscomparedtocontrols. IL-6 levels were significantly elevated in both exposure groups, with the Arg/Arg genotype of TP53 codon 72 being more prevalent in the long-term exposure group (52%) compared to controls (5%). Workers with the Arg/Arg genotype exhibited significantly higher IL-6 concentrations than those with Pro/Pro or Arg/Pro genotypes in both exposure groups. The findings suggest that the TP53 Arg/Arg genotype may increase susceptibility to environmental toxins, highlighting the role of genetic factors in individual responses to occupational exposures. This study underscores the importance of genetic screening and monitoring in workers exposed to environmental hazards