Hyperthermia, which involves the controlled application of heat, has been explored as a potential therapy for infectious diseases. This innovative approach applied upraised temperatures to boost immunological responses and directly disrupt pathogens viability. Hyperthermia can ameliorate the body’s ability to fight infections by stimulating the immunesystemandgrowing,thecirculation of immune cells. Furthermore, upraised temperatures could negatively influence pathogen’s viability and virulence, making them less able to cause disease. When used as an adjunct therapy alongside traditional treatments, hyperthermia has the potential to upgrade patient’s outcomes by working synergistically with other therapeutics modalities. However, several challenges must be considered to ensure the effectiveness and safety of this suggested treatment. If proven effective, hyperthermia could be a valuable inclusion to the present arsenal of treatments for infections agents, offering a novel approach to boosting immunological functions and directly targeting pathogens. This review provides a comprehensive overview of the importance of using fever therapy in combating infectious diseases, especially in light of the rapid developmentofantibioticresistanceamongpathogens.Thereviewpresentsimportantpathways for the use of heat as a therapeutic agent or as an adjuvant to conventional therapies. Each pathway described in this paper could open new avenues for future studies on combating bacterial infections using heat therapy.