Critical limb ischemia (CLI) is a severe manifestation of peripheral arterial disease characterized by rest pain, non-healing ulcers, and a high risk of limb loss. This study evaluates the efficacy of various endovascular interventions in treating CLI over a two-year period, analyzing limb salvage rates, vascular patency, and the need for reintervention. A total of 150 patients underwent either stenting or balloon angioplasty, with follow-up assessments utilizing contrast-enhanced CTangiography or Doppler ultrasound. Findings indicate a limb salvage rate of 92%, with infragenicular lesions exhibiting the lowest vascular durability (45% patency rate) and the highest requirement for redo percutaneous angiography (31.6%). These results underscore the effectiveness of minimally invasive techniques in CLI management, while emphasizing the need for advancements in restenosis prevention. Future strategies should focus on drug-eluting technologies and regenerative approaches, particularly stem cell therapy, to enhance long-term outcomes.