The spectrum of pericardial diseases consists of congenital defects, pericarditis (dry, effusive, effusive-constrictive, and constrictive), neoplasm, and cysts. The aetiological classification comprises: infectious pericarditis, pericarditis in systemic autoimmune diseases, type 2 (auto) immune process, postmyocardial infarction syndrome, and auto-reactive (chronic) pericarditis.We report a case of 62-year-old patient with recurring pericardial and pleural fluid, who was diagnosed with undetermined cause infection. She was successfully treated with antibiotics, colchicine, non steroidal anti inflammatory drugs (NSAIDs) In this report we discuss actual recommendations on diagnosis and management of pericardial diseases in adult patients. JRCD 2015; 2 (3): 92–95